Fletcher Factor Deficiency: Family Study and Detection
نویسندگان
چکیده
منابع مشابه
Fletcher factor deficiency: family study and detection.
Eight of 1 1 children of a known Fletcher taming celite or kaolin were sensitive to factor-deficient individual were found to Fletcher factor deficiency, while one rehave normal activated partial thromboagent containing ellagic acid did not deplastin times, normal levels of factors VIII, tect this abnormality. The finding of an IX, Xl, and XII, and a mean Fletcher factor abnormal partial thromb...
متن کاملPrekallikrein (Fletcher factor) deficiency.
One new case and 29 reported cases of hereditary prekallikrein (Fletcher factor) deficiency are reviewed. Abnormalities in the coagulation, fibrinolytic, complement, and kinin systems are described. These cases are discovered incidentally by prolonged partial thromboplastin times (PTTs) which correct with extended incubation in the presence of a contact activator. Prekallikrein levels are less ...
متن کاملProlonged Partial Thromboplastin Time Without Bleeding History; Fletcher Factor Deficiency.
A 67-year-old patient was admitted to the hospital to perform an esophagogastrectomy because a lesion at the lower esophagus was strongly suspicious for cancer. Her medical history and her family history were negative for bleeding tendency or thrombosis. Her activated partial thromboplastin time (aPTT) was prolonged (44 s) whereas her prothrombin time (PT) was normal (11 s) presurgery. Mixing o...
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Inherited complement deficiencies are associated with a variety of connective tissue diseases. A family with inherited deficiency of complement factor 2 (C2) is described in which two family members with homozygous C2 deficiency developed cutaneous vasculitis and siccasyndrome. The otherfamily members had heterozygous C2 deficiency and each member had the HLA-A25, B18, DR2 (w15) haplotype. The ...
متن کاملSevere prekallikrein (Fletcher factor) deficiency due to a compound heterozygosis (383Trp stop codon and Cys529Tyr).
We investigated a family with prekallikrein deficiency, using both standard coagulation tests and molecular biology techniques. The propositus was found to be a compound heterozygote for a Trp383 stop codon and a Cys529Tyr point mutation. The former mutation was located in exon 11, the latter in exon 14. The propositus inherited the first defect from his father and the second from his mother. B...
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ژورنال
عنوان ژورنال: Blood
سال: 1974
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood.v43.5.641.641